ASPR Strategic Plan FY 2026–2029 The Administration for Strategic Preparedness and Response's strategic plan for fiscal years 2026–2029, aligning health security priorities with President Trump's executive orders on state resiliency and pharmaceutical onshoring, HHS Secretary Kennedy's vision to make America healthy and safe again, and the responsibility of fiscal stewardship on behalf of the American taxpayer. ASPR is the nation's lead health security agency — driving preparedness before disaster strikes, securing domestic medical supply chains, advancing gold standard science, and delivering a fast, accountable federal response when lives are on the line. ^^ The plan is organized around five goals: empowering the workforce and reinforcing a "One ASPR" culture; helping strengthen preparedness and resiliency of state and local governments; executing rapid, efficient, and adaptive federal response; securing America's medical supply chain; and addressing emerging health security threats. ^^ The plan was released January 9, 2026, and is published in Version 1.1. ^^ Submitter's Note: This StratML rendition was produced by Claude.ai and review in the form at https://stratml.us/forms/Claude/Part1.html Administration for Strategic Preparedness and Response ASPR 93bc3bab-886c-4d3d-9eb2-4452f0f7762a ASPR is a division of the U.S. Department of Health and Human Services and serves as the nation's lead health security agency. ASPR partners with states, local communities, tribes, territories, other federal agencies, and the private sector to strengthen readiness, invests in American manufacturing to reduce foreign dependency, and stewards taxpayer resources with transparency, discipline, and measurable outcomes. John Knox Principal Deputy Assistant Secretary for Strategic Preparedness and Response U.S. Department of Health and Human Services A resilient nation where every community is prepared for disasters and public health emergencies while supported by a secure domestic medical supply chain, gold standard science, and a rapid, accountable federal response. 9b5ae52b-7720-4b33-ba2f-938ace1a9814 ASPR protects the American people and ensures that the United States can prepare for, respond to, and recover from any threat to national security, anytime, anywhere — before, during, and after crises. ac824ba1-0c14-4782-ba63-bfb4f55e686b Health Security Health security is a core component of national security; ASPR's work to prepare for and respond to public health emergencies directly protects the safety and sovereignty of the United States. Partnership Effective preparedness and response require a collective approach — ASPR builds strong federal-state-local partnerships in advance of crises, partnering with SLTT governments, the private sector, communities, families, and individuals. Fiscal Responsibility ASPR stewards taxpayer resources with transparency, discipline, and measurable outcomes, ensuring funding aligns with national priorities and eliminates waste. Scientific Integrity ASPR advances gold-standard, transparent, and unbiased science to guide federal preparedness investments, emphasizing reproducible research and demonstrably effective tools. Unity of Effort ASPR fosters a "One ASPR" culture of teamwork, mutual respect, and professional development across its centers, eliminating silos to strengthen the organization's collective capacity to execute its mission. Workforce Empowerment Empower the workforce and reinforce a "One ASPR" culture by increasing cross-center coordination, reducing duplication of effort, and building an empowered, engaged, talented, and trained workforce operating within an organization that values collaboration and transparent communication. 7b7e6783-c411-4833-9fac-e80135100ecf 1 ASPR Workforce ASPR employees across all centers whose expertise, commitment, and service form the foundation of national health security readiness and response. Goal 1 ~ Empower the Workforce and Reinforce a "One ASPR" Culture: ASPR will pair effective and agile collaborative work across its centers — Center for Administration, Center for Preparedness, Center for Response, Center for the Strategic National Stockpile, Center for the Biomedical Advanced Research and Development Authority, Center for Industrial Base Management and Supply Chain, and the Immediate Office of the ASPR — with cultural reinforcement to strengthen unity of effort while preserving center-level expertise. Cross-Center Integration Improve integration across ASPR centers to eliminate silos of information or activity by increasing cross-center coordination and reducing duplication of effort, reinforcing a "One ASPR" culture of teamwork, mutual respect, and service. 4740a01e-413d-4c9a-9f7e-3ace8898b519 1.1 Workforce Readiness Promote an adaptable, engaged, well-trained workforce to improve operational readiness, employee resilience, and capability to carry out the ASPR mission through targeted training and professional development. c5dd1abf-1a09-4ac0-9eda-e0e1f7a4553e 1.2 State and Local Resiliency Help strengthen preparedness and resiliency of state and local governments by empowering SLTT partners to identify, prepare for, and mitigate evolving threats and hazards through risk-informed decisions and smart investments, and providing adaptive support when health systems become overwhelmed. bd6320c4-fa35-421d-a096-41312b95fdf9 2 State, Local, Tribal, and Territorial Partners SLTT governments, health care coalitions, and community organizations whose preparedness capacity ASPR strengthens through guidance, resources, training, and planning tools. Goal 2 ~ Help Strengthen Preparedness and Resiliency of State and Local Governments: Strengthening disaster resilience and readiness requires a collective approach from all levels of government, the private sector, communities, families, and individuals. ASPR implements President's Executive Order 14239 on achieving efficiency through state and local preparedness. Key programs include the Hospital Preparedness Program (HPP) and the National Special Pathogen System (NSPS), with emphasis on performance-based readiness metrics and improved supply chain visibility for medical countermeasures. SLTT Preparedness Support Support SLTT partners with the guidance, resources, training, and planning tools necessary to implement the President's Executive Order 14239 on achieving efficiency through state and local preparedness, improving coordination and strengthening health systems that are reliable and ready to perform under pressure. c6c2dcaa-b9b1-4cd4-9b40-8f2f1396b59d 2.1 Readiness Metrics Establish and apply performance-based readiness metrics to assess SLTT preparedness capacity and target investments where they will most effectively strengthen state and local health system resilience and readiness. 0b1fae9c-3ad5-4307-8a7b-1c717c26027d 2.2 MCM Distribution Capacity Strengthen SLTT capacity to receive, distribute, and administer medical countermeasures (MCMs) and improve supply chain visibility to ensure that lifesaving products reach communities rapidly during emergencies. 67963d3e-83e2-437e-af5d-daafa2804286 2.3 Federal Response Execute rapid, efficient, and adaptive federal response by maintaining deployable federal medical response teams, strengthening operational coordination, and ensuring ASPR responders and SLTT partners are equipped with the skills needed to protect lives and stabilize health systems when large-scale disasters or public health emergencies overwhelm SLTT resources. bc3d1ca2-4f9e-4431-8d9b-d8ffdf98f044 3 Disaster-Affected Communities Communities and individuals affected by large-scale disasters, public health emergencies, or national security threats whose lives and health systems ASPR federal response teams are deployed to protect and stabilize. Goal 3 ~ Execute Rapid, Efficient, and Adaptive Federal Response: When large-scale disasters or public health emergencies overwhelm SLTT resources, a swift, coordinated federal response is critical. Deployable federal medical response teams are maintained using continuously updated models focused on life-saving outcomes and rapid deployment of personnel and resources. The Strategic National Stockpile is a key asset maintained under this goal. Federal Response Assets Maintain deployable federal medical response teams and support non-federal response assets based on efficient and updated models focused on life-saving outcomes and rapid deployment of personnel and resources to disaster-affected areas. 58a55433-6273-4e4a-a9b3-d60520fe38ee 3.1 Operational Coordination Strengthen operational coordination by establishing clear lines of authority in disaster response to rapidly deploy responders and coordinate seamlessly with federal and SLTT partners when called upon. 94986660-a7cc-4541-b539-100c088c0bff 3.2 Responder Training Develop a core competency framework for disaster training to ensure ASPR responders and SLTT partners are equipped with the response skills needed to effectively protect lives during any type of emergency. 79a6f7ac-f4ec-459c-9cba-12ca180a4093 3.3 Strategic National Stockpile Maintain the Strategic National Stockpile to safeguard the nation's health by ensuring critical medicines, vaccines, medical supplies, and equipment are available and deployable during public health emergencies. e9ad0e97-f2a5-4cae-8b34-2e779b90d623 3.4 Medical Supply Chain Secure America's medical supply chain by bolstering domestic manufacturing of critical medicines, devices, personal protective equipment, and other medical supplies to reduce dependence on concentrated foreign sourcing and ensure lifesaving products are available during emergencies. c9eaae9d-754c-48db-bdbb-b6c9761135a7 4 Domestic Manufacturers and Health Care System U.S. manufacturers of critical medicines, active pharmaceutical ingredients, key starting materials, medical devices, and personal protective equipment whose capacity ASPR works to strengthen and whose products protect the American public during emergencies. Goal 4 ~ Secure America's Medical Supply Chain: The United States continues to be reliant on concentrated foreign sourcing of critical medicines, which can be impacted by shipping delays, geopolitical tensions, trade disruptions, and disasters. This goal implements President Trump's executive orders on pharmaceutical onshoring and aligns with Administration-wide efforts to reduce foreign dependency. BARDA's Center for Industrial Base Management and Supply Chain leads key actions under this goal. Domestic Manufacturing Bolster domestic manufacturing of critical medicines and their components, including active pharmaceutical ingredients (APIs) and key starting materials (KSMs), to reduce dependency on foreign sourcing and strengthen the resilience of the U.S. medical supply chain. 1f1b190b-2b30-485f-8ea4-4620d180f694 4.1 Manufacturing Onshoring Incentivize the onshoring of manufacturing and minimize barriers to make it easier for industry to produce domestic medical countermeasures and medical supplies, supporting the President's executive orders on pharmaceutical onshoring. 2ded2b04-dbab-44ef-b6bd-fc8b790016f1 4.2 Supply Chain Transparency Collaborate with stakeholders to identify innovative and agile manufacturing models and increase transparency in U.S. medical supply chain vulnerabilities to enable better risk-informed decisions and targeted investments. 0d474c70-ef58-446c-9bd5-9f0d8c0dbc25 4.3 Health Security Threats Address emerging health security threats by supporting safe, transparent, and unbiased research to guide federal investments in countering chemical, biological, radiological, and nuclear (CBRN) threats and future pandemics, while advancing gold-standard science with integrity and measurable outcomes. 0400b059-f463-47a3-a6b0-17536f8121f8 5 Research Community and Public Health Partners Researchers, scientists, public health agencies, and health care organizations engaged in advancing preparedness-driven science and developing medical countermeasures against CBRN threats and pandemic pathogens. Goal 5 ~ Address Emerging Health Security Threats: ASPR emphasizes transparent and reproducible research, reduced reliance on animal testing where scientifically appropriate, improved research integrity, and selective integration of digital health tools and artificial intelligence where they demonstrably improve preparedness. BARDA leads key research and development actions under this goal, advancing medical countermeasures against CBRN threats and future pandemics. Gold-Standard Science Support safe, transparent, and unbiased research that is reproducible and integrity-driven to guide federal investments in countering CBRN threats and future pandemics, emphasizing demonstrably effective approaches and measurable preparedness outcomes. 8a2ef26d-492b-490e-ade4-d707dc196816 5.1 MCM Development Advance the research, development, and acquisition of medical countermeasures (MCMs) against CBRN threats and emerging pandemic pathogens, including selective integration of digital health tools and artificial intelligence where they demonstrably improve preparedness capabilities. fa96f7d1-7459-41da-8ba0-327fc4ce6e24 5.2 2026-10-01 2029-09-30 2026-06-13 https://aspr.hhs.gov/StratPlan/Pages/default.aspx Owen Ambur Owen.Ambur@verizon.net