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MSM can be critically beneficial for implementing policies and guidelines - ultimately accelerating the research and development enterprise.</Description><OtherInformation>MSM Definition ~ Multiscale biological, biomedical and behavioral modeling (MSM) uses mathematics, statistics and computation to represent, simulate, and mechanistically define and predict system function across spatial scales (atomic, molecular, macromolecular complex, organelle, cellular, tissue, organ, multi-organ, organismal, behavioral, population) and temporal scales (nanoseconds, microseconds, milliseconds, seconds, minutes, hours, years).  Biological, biomedical and behavioral mechanisms include physics-based, chemistry-based principles.  </OtherInformation><StrategicPlanCore><Organization><Name>Interagency Modeling and Analysis Group</Name><Acronym>IMAG</Acronym><Identifier>_009ef0f0-1ab1-11ee-b736-de920f83ea00</Identifier><Description/><Stakeholder StakeholderTypeType="Organization"><Name>Department of Health and Human Services</Name><Description>BARDA</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Carlos Arguello Ortiz</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Eun Mi Lee</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Generic_Group"><Name>IMAG Agencies</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Organization"><Name>National Institute of Health</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Leonardo Angelone</Name><Description>NIDA</Description></Stakeholder><Stakeholder 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Quatrano</Name><Description>NCMRR/NICHD</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Haluk Resat</Name><Description>OD</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Asif Rizwan</Name><Description>NHLBI</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Andrew Rossi</Name><Description>NIMH</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Merav Sabri</Name><Description>NIDCD</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Salvatore Sechi</Name><Description>NIDDK</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Heidi Sofia</Name><Description>NHGRI</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Barbara Sorkin</Name><Description>OD</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Coryse St Hillaire-Clarke</Name><Description>NIA</Description></Stakeholder><Stakeholder 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Whang</Name><Description>CISE/IIS</Description></Stakeholder><Stakeholder StakeholderTypeType="Organization"><Name>National Aeronautics and Space Administration</Name><Description>NASA - Human Research Program</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Jennifer Fogarty</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Devon Griffin</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Beth Lewandowski</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Jerry Myers</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Organization"><Name>Department of Energy</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Ramana Madupu</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Organization"><Name>Department of Defense</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Joshua Elliott</Name><Description>DARPA</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Daniel Adams</Name><Description>DARPA</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Mary Kratz</Name><Description>PEPFAR</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Harvey Magee</Name><Description>TATRC, USAMRMC</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Pedja Neskovic</Name><Description>ONR</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Virginia Pasour</Name><Description>ARL</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Fariba Fahroo</Name><Description>AFOSR</Description></Stakeholder><Stakeholder StakeholderTypeType="Organization"><Name>United States Department of Agriculture</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Organization"><Name>United States Department of Veteran's Affairs</Name><Description>USDVA</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Brian Schulz</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Organization"><Name>U.S. Food and Drug Administration</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Jane Bai</Name><Description>(CDER)</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Dorn Carranza</Name><Description>(CDRH)</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Tina Morrison</Name><Description>(OCS)</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Pras Pathmanathan</Name><Description>(CDRH)</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Sandy Weininger</Name><Description>(CDRH)</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Elena Sizikova</Name><Description>(CDRH)</Description></Stakeholder><Stakeholder StakeholderTypeType="Organization"><Name>Office of the Director of National Intelligence (ODNI)</Name><Description>Intelligence Advanced Research Projects Activity (IARPA)</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>David Markowitz</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Jennifer Wang</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Organization"><Name>Agency for Healthcare Research and Quality</Name><Description>HHS/AHRQ</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Kerm Henriksen</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>David Rodrick</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Organization"><Name>Centers for Disease Control and Prevention</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>John Glasser</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Rachel Slayton</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Organization"><Name>Office of Naval Research</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Organization"><Name>Army Research Laboratory</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Organization"><Name>Biomedical Advanced Research and Development Authority</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>James Warren</Name><Description>NIST</Description></Stakeholder><Stakeholder StakeholderTypeType="Generic_Group"><Name>MSM Participants</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Geoffrey Abbott, Ph.D.</Name><Description>Predictive MSM of Atrial Fibrillation for Therapy Development</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Gary An, M.D.</Name><Description>Agent-based Models to address the Crisis of Reproducibility and Precision Medicine | Population
</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Kurt Anderson, Ph.D.</Name><Description>Framework for the Adaptive Multiscale Modeling of Biopolymers</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Russ Altman, M.D., Ph.D.</Name><Description>Physics-Based Simulation of Biological Structures</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Bruce Ayati</Name><Description>NIAMS: CORT Innovations to Assess and Forestall Post-Traumatic Osteoarthritis | Biomechanics, Cell-to-Macroscale</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Portonovo Ayyaswamy</Name><Description>Bridging multiple scales in modeling targeted drug nanocarrier delivery</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Victor Barocas, Ph.D.</Name><Description>Multiscale Modeling of Facet Capsule Mechanobiology; Multiscale Mechanics of Bioengineered Tissues</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>James (Jim) Bassingthwaighte, M.D., Ph.D.</Name><Description>Software Integration between JSim and Systems Biology Workbench; Modeling for Heart, Lung, and Blood: From Cell to Organ; Adaptive Multi-Scale Model Simulation, Reduction and Integration for Cardiac Muscle Physiology | *Co-leader of Model and Data Sharing Working Group</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Daniel Beard, Ph.D.</Name><Description>Multi-Scale Modeling of the Heart in Metabolic Syndrome and Cardiovascular Disease, Mechanisms of Metabolic Dysfunction in Heart Disease | Multiscale Systems Biology Working Group</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Scott Berceli, M.D., Ph.D.</Name><Description>Multiscale Network Modeling of Hemodynamically-Driven Vascular Adaptation</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Theodore Berger</Name><Description>Predictive modeling of bioelectric activity on mammalian multilayered neuronal structures in the presence of supraphysiological electric fields | *Co-leader of Computational Neuroscience Working Group</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Jeff Bischoff, Ph.D.</Name><Description>Research Interests: Multiscale Joint Biomechanics</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Michael Blinov</Name><Description>National Resource for Cell Analysis and Modeling</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Danny Bluestein, Ph.D.</Name><Description>Multiscale Modeling of Blood Flow and Platelet Mediated Thrombosis</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Georgiy Bobashev</Name><Description>Researching Social Dynamics of Local Methamphetamine Market</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>James Bower, Ph.D.</Name><Description>GENESIS</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Patrick M Boyle, PhD</Name><Description>Simulation guidance of ablation therapy for persistent atrial fibrillation | Model and Data Sharing Working Group</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>James Brasseur, Ph.D.</Name><Description>Micro-scale Transport as a Critical Link between Molecular-Scale Absorption and Macro-Scale Mixing in Gut Physiology and Function</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Markus Buehler, Ph.D.</Name><Description>Models to predict protein biomaterial performance | *Co-leader of IMuBEAM	</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>David Cai</Name><Description>Collaborative Research: Cortical Processing across Multiple Time- and Space-Scales</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>William Cannon, Ph.D.</Name><Description>Hierarchical, Multi-Objective Optimization of Microbial Community Proteomic Systems | *Co-leader of Theoretical and Computational Methods</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Ross Carlson, Ph.D.</Name><Description>Predictive Multiscale Modeling of Microbial Consortia Biofilms | *Co-leader of Cell-to-Macroscale Working Group
</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Xiaolin Cheng, Ph.D.</Name><Description>Multiscale Mathematics and Simulations of Complex Biological Systems</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Howard Chizeck, Sc.D.</Name><Description>Adaptive Multi-Scale Model Simulation, Reduction and Integration for Cardiac Muscle Physiology</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Yoonsuck Choe, Ph.D.</Name><Description>Multi-Scale Imaging, Analysis, and Integration of Brain Networks</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Brent Craven</Name><Description>FDA project webpage	Brent.Craven@fda.hhs.gov	Biomechanics; Theoretical and Computational Methods; Committee on Credible Practice of Modeling &amp; Simulation in Healthcare</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Sharon Crook, Ph.D.</Name><Description>NeuroML Standards and Tools for Multiscale Model Specification and Exchange</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>David Christini, Ph.D.</Name><Description>Predictive MSM of Atrial Fibrillation for Therapy Development</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Ming Dao, Ph.D.</Name><Description>Multiscale Modeling and Parallel Simulations of Blood Flow in Cerebral Malaria and Sickle Cell Diseases</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>David D'Argenio, Ph.D.</Name><Description>Biomedical Simulations Resource: Core Project #1 - Pharmacokinetic/Pharmacodynamic Systems Analysis</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Suvranu De, Sc.D.</Name><Description>A Self-Consistent Multiscale Method for Modeling the Effects of Neutron Irradiation on the Mechanical Properties of BCC and FCC Metals; Nonlinear Multiscale Modeling of 3D Woven Fiber Composites Under Ballistic Loading; Development of a Self-Consistent Multiscale Method for Coupled Nonlinear Micro Macro Analysis of Heterogeneous Explosives</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Thomas Deisboeck, M.D.</Name><Description>Center for the Development of a Virtual Tumor, CViT</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Scott Delp, Ph.D.</Name><Description>Physics-Based Simulation of Biological Structures</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Angela DePace, Ph.D.</Name><Description>Multi-scale modeling of genetic variation in a developmental network</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Yasin Dhaher</Name><Description>A Multi-Scale Modeling Construct of Knee Mechanics following ACL Reconstruction | *Co-leader of Biomechanics Working Group</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Thomas Diacovo, M.D.</Name><Description>Model of Platelet Adhesion and Thrombus Formation</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Scott Diamond, Ph.D.</Name><Description>(Talid Sinno, Lawrence (Skip) Brass) | Theoretical and Computational Methods; Clinical and Translational Issues Working Group</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>David Eckmann, M.D., Ph.D.</Name><Description>Bridging multiple scales in modeling targeted drug nanocarrier delivery // Targeted Microcarrier Design and Optimization | Clinical and Translational Issues Working Group</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Uri Tzvi Eden</Name><Description>Multiscale analysis and modeling of spatiotemporal dynamics in human epilepsy </Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Daniel Einstein</Name><Description>3D Imaging &amp; Computer Model of the Respiratory Tract</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Mounya Elhilali</Name><Description>Multi-scale modeling of the cocktail party problem | Computational Neuroscience  </Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Ahmet Erdemir, Ph.D.</Name><Description>Efficient Methods for Multi-Domain Biomechanical Simulations, Predicting Cell Deformation from Body Level Mechanical Loads, Open Knee: A Three-Dimensional Finite Element Representation of the Knee Joint | Biomechanics Working Group, Model and Data Sharing Working Group, *Co-leader of Committee on Credible Practice of Modeling and Simulation in Healthcare	</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Arthur Erdman, Ph.D.</Name><Description>Modeling, Simulation, and Visualization for Medical Device Design</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Stephen Eubank, Ph.D.</Name><Description>Modeling Immunity to Enteric Pathogens (MIEP)</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Ronan Fleming, Ph.D.</Name><Description>Numerical Optimization Algorithms and Software for Systems Biology | Multiscale Systems Biology Working Group
</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Joanne Flynn, Ph.D.</Name><Description>A multi-scale model to predict outcomes of immuno- modulation and drug therapy during TB</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Alison Galvani</Name><Description>Evaluating the social influences that impact vaccination decisions; Impacts of Individual and Social Behavior on Influenza Dynamics and Control | *Co-leader of Population Modeling Working Group</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Marc Garbey</Name><Description>Multiscale Network Modeling of Hemodynamically-Driven Vascular Adaptation | Clinical and Translational Issues Working Group</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Guy Genin</Name><Description>Cross-scale interactions between mineral and collagen for tendon-bone attachment | *Co-leader of IMuBEAM
</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Frank Gertler</Name><Description>Modeling bi-directional signaling and cytoskeletal dynamics in 3D cell migrations</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>James Glazier</Name><Description>CompuCell3D</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Mark Gordon, Ph.D.</Name><Description>Multiscale Mathematics and Simulations of Complex Biological Systems</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Richard Gray</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Weiyong Gu</Name><Description>Biomechanics </Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Trent Guess, Ph.D.</Name><Description>Dynamic Simulation of Joints Using Multi-Scale Modeling</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Runesha B. Hakizumwami, Ph.D.</Name><Description>Modeling, Simulation, and Visualization for Medical Device Design</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Randy Heiland, M.S.</Name><Description>CompuCell3D</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>John Higgins</Name><Description>Multiscale Modeling of Sickle Cell Anemia: Methods and Validation</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Anthony Hunt, Ph.D.</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Jay Humphrey, Ph.D.</Name><Description>Evolving Mechanics of Intraluminal Thrombus: From Formation to Organization</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Peter Hunter, Ph.D.</Name><Description>International Union of Physiological Sciences Council Member | Co-leader of Model and Data Sharing Working Group </Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Dov Jaron</Name><Description>Multiscale, Transport-Dependent NO Signaling: Cells to Vascular Networks</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Paul Jasper</Name><Description>Numerical Tools for Analyzing Cell Signaling Circuits in Normal and Tumor Cells</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Karl Jepsen</Name><Description>Genetic Determination of Skeletal Fragility</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Yufang Jin, Ph.D.</Name><Description>Mathematical Modeling of Matrix Metalloproteinase-9 Driven Left Ventricular Remodeling Post Myocardial Infarction | High Performance Computing Working Group</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Wolfgang Kainz, PhD</Name><Description>Development of a functional ultra-high resolution head model</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Roger Kamm, Ph.D.</Name><Description>Modeling bi-directional signaling and cytoskeletal dynamics in 3D cell migrations Multi-Scale Analysis of Cellular Force Transmission and Biochemical Activation</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>David Kaplan, Ph.D.</Name><Description>Models to Predict Protein Biomaterial Performance</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>George Karniadakis, Ph.D.</Name><Description>A Stochastic Molecular Dynamics Method for Multiscale Modeling of Blood Platelet Phenomena | Theoretical and Computational Methods</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Daniel Keefe, Ph.D.</Name><Description>Modeling, Simulation, and Visualization for Medical Device Design.</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Michael King</Name><Description>Model of Platelet Adhesion and Thrombus Formation | Multiscale Systems Biology Working Group</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Denise Kirschner, Ph.D.</Name><Description>A multi-scale model to predict outcomes of immuno- modulation and drug therapy during TB | Multiscale Systems Biology Working Group</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Gregor Kovacic, Ph.D.</Name><Description>Collaborative Research: Cortical Processing across Multiple Time- and Space-Scales</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Mark Kramer</Name><Description>Multiscale analysis and modeling of spatiotemporal dynamics in human epilepsy</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Joy Ku, Ph.D.</Name><Description>Physics-Based Simulation of Biological Structures | Model and Data Sharing Working Group	</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Niels Kuster</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Rob Kunz, Ph.D.</Name><Description>Multi-Scale Human Respiratory System Simulations to Study the Health Effects of Aging, Disease and Inhaled Substances</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Anthony (Tony) Ladd, Ph.D.</Name><Description>Multi-Scale Modeling of Chemical-to-Mechanical Energy Conversion in Actin-Based Motility</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Nicola Lai, Ph.D.</Name><Description>(in place of Marco Cabrera) Time Course of Metabolic Adaptations During Loading and Unloading</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Robert Latour, Ph.D.</Name><Description>IMuBEAM</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Gianluca Lazzi</Name><Description>Predictive modeling of bioelectric activity on mammalian multilayered neuronal structures in the presence of supraphysiological electric fields</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Peter Laz</Name><Description>A Multi-Scale Finite Element Musculoskeletal Modeling Framework Applied to Current Issues in Joint Replacement</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Jonathan Lederer</Name><Description>Calcium Entrained Arrhythmias</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Nicole Yee-Key Li-Jessen</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Ching-Long Lin, Ph.D.</Name><Description>An integrative statistics-guided image-based multi-scale lung model; Multiscale Simulation of Gas Flow Distribution in the Human Lung	| *Co-leader of Cell-to-Macroscale Working Group</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Jennifer Linderman, Ph.D.</Name><Description>A multi-scale model to predict outcomes of immuno- modulation and drug therapy during TB</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Yaling Liu, Ph.D.</Name><Description>Modeling Particle Shape Effect in Nanomedicine</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Leslie Loew</Name><Description>National Resource for Cell Analysis and Modeling | Multiscale Systems Biology Working Group
</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Georg Luebeck, Ph.D.</Name><Description>Scales of Carcinogenesis: Cells, Crypts and Cancer; Controlling Esophageal Cancer in the US.: A Colloraborative Modeling Project</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Bill Lytton, M.D.</Name><Description>Extension of NEURON Simulator for Simulation of Reaction-Diffusion in Neurons ; NEURON Simulator | Clinical &amp; Translational; *Co-leader of Computational Neuroscience</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Carlo Maley, Ph.D.</Name><Description>Scales of Carcinogenesis: Cells, Crypts and Cancer</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Parag Mallick</Name><Description>Multi-scale Complex Systems Transdisciplinary Analysis of Response to Therapy</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Madhav Marathe, Ph.D.</Name><Description>Modeling Immunity to Enteric Pathogens (MIEP) | *Co-leader of Population Modeling Working Group</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Roger Mark, M.D., Ph.D.</Name><Description>Physionet | *Co-leader of Model and Data Sharing Working Group	 </Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Vasilis Marmarelis, Ph.D.</Name><Description>Biomedical Simulations Resource (BMSR) [Mathematical &amp; Computational Methods]</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Andrew McCulloch, Ph.D.</Name><Description>Multi-Scale Modeling of the Mouse Heart: From Genotype to Phenotype | Multi-Scale Modeling of the Failing Heart for Cardiac Rysynchronization Therapy</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Jill McNitt-Gray, Ph.D.</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Michael Meyer-Hermann, Ph.D.</Name><Description>Mathematical Modeling of the Migration in Germinal Centres</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>George Moody</Name><Description>Physionet | Model and Data Sharing Working Group</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>James Moore, Ph.D.</Name><Description>Lymphatic Fluid Flow Modeling with Active Network Components | Biomechanics Working Group</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Ion Moraru</Name><Description>National Resource for Cell Analysis and Modeling</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Lealem Mulugeta</Name><Description>*Co-leader of Committee on Credible Practice of Modeling and Simulation in Healthcare</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Wendy Murray</Name><Description>Prosthesis Control by Forward Dynamic Simulation of the Intact Biomedical System</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Mark Musen, M.D., Ph.D.</Name><Description>The National Center for Biomedical Ontology</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Sriram Neelamegham</Name><Description>Systems Biology of Glycosylation</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Sergey Nuzhdin</Name><Description>*Co-leader of Population Modeling Working Group</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Peter Ortoleva</Name><Description>Intercellular Genomics of Subsurface Microbial Colonies</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Manish Parashar</Name><Description>	 
</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Pras Pathmananthan, Ph.D.</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Abani Patra, Ph.D.</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Bernhard Palsson</Name><Description>Numerical Optimization Algorithms and Software for Systems Biology</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Linda Petzold, Ph.D.</Name><Description>Stochastic Simulation Service: A Cloud Computing Framework for Modeling and Simulation | Theoretical and Computational Methods</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Teresa Pitts, Ph.D.</Name><Description>Regulation of Airway Protection | Computational Neuroscience Working Group</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Sylvia Plevritis</Name><Description>Comparative Modeling of Lung Cancer Control Policies</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Aleksander Popel</Name><Description>Predictive Experiment-Based Multiscale Models of Angiogenesis in Breast Cancer | Multiscale Systems Biology Working Group</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Vito Quaranta</Name><Description>Image Driven Multi-Scale Modeling to Predict Treatment Response in Breast Cancer | Multiscale Systems Biology Working Group</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Ravi Radhakrishnan</Name><Description>Bridging multiple scales in modeling targeted drug nanocarrier delivery // Lab URL | Multiscale Systems Biology Working Group; Theoretical and Computational Methods; *Co-leader of High Performance Computing Working Group</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>John Rice</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Peter Richardson</Name><Description>A Stochastic Molecular Dynamics Method for Multiscale Modeling of Blood Platelet Phenomena</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Paul Rullkoetter</Name><Description>A Multi-Scale Finite Element Musculoskeletal Modeling Framework Applied to Current Issues in Joint Replacement</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Ilya Rybak, Ph.D.</Name><Description>Multiscale Model of Neural Control of Breathing</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Gerald Saidel, Ph.D.</Name><Description>(in place of Marco Cabrera)	Time Course of Metabolic Adaptations During Loading and Unloading</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Edward Sander, Ph.D.</Name><Description>Controlling the Mechanobiology of Cutaneous Wounds to Reduce Hypertrophic Scar	edward-sander@uiowa.edu	*Co-leader of </Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Terence Sanger, M.D., Ph.D.</Name><Description>High Speed Simulation of Developmental Motor Disorders | *Co-leader of Clinical and Translational Issues Working Group</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Michael Saunders</Name><Description>Numerical Optimization Algorithms and Software for Systems Biology</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Herbert Sauro, Ph.D.</Name><Description>Software Integration between JSim and Systems Biology Workbench, Modeling for Heart, Lung, and Blood: From Cell to Organ | *Co-leader of Model and Data Sharing Working Group</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Jay Schieber</Name><Description>CISE: Multiscale Modeling to Develop a Cyberinfrastructure for the Dynamics of Flexible and Stiff Entangled Macromolecules</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Steven Schiff</Name><Description>CRCNS Collaborative Research: Model-Based Control of Spreading Depression</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Bill Schultz</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>James Schwaber</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Timothy W. Secomb</Name><Description>Multiscale modeling of cerebral blood flow and oxygen transport</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Daniel Segre</Name><Description>An Open Source Platform for Multi-Scale Spatially Distributed Simulations of Microbial Ecosystems</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Terrence (Terry) Sejnowski, Ph.D.</Name><Description>Integrated Empirical and Multiscale Modeling of Human Sleep Spindles</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Kevin Shelburne</Name><Description>A Multi-Scale Finite Element Musculoskeletal Modeling Framework Applied to Current Issues in Joint Replacement</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Yohannes Shiferaw</Name><Description>MSM of Calcium Mediated Triggered Activity in the Heart</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>James (Jim) P. Sluka, Ph.D.</Name><Description>Biocomplexity Institute and Multiscale Models Liver biology and Toxicology</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Jeff Smith, Ph.D.</Name><Description>Multiscale Model of Neural Control of Breathing</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Jeremy Smith</Name><Description>Multiscale Mathematics and Simulations of Complex Biological Systems</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Subra Suresh, Sc.D.</Name><Description>Multiscale Modeling and Parallel Simulations of Blood Flow in Cerebral Malaria and Sickle Cell Diseases</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Maciej Swat, Ph.D.</Name><Description>Multiscale Studies of Segmentation in Vertebrate Embryos	</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Dalin Tang, Ph.D.</Name><Description>In Vivo IVUS Image-Based Modeling for Human Coronary Plaque Assessment</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Michela Taufer, Ph.D.</Name><Description>DAPLDS: A Dynamically Adaptive Protein-Ligand Docking System Based on Multi-Scale Modeling</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Merryn Tawhai, Ph.D.</Name><Description>Airway Hyperresponsiveness: From Molecule to Organ</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Darryl Thelen</Name><Description>A Multi-Scale Modeling Construct of Knee Mechanics following ACL Reconstruction</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Ines Thiele</Name><Description>Numerical Optimization Algorithms and Software for Systems Biology</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Stavros Thomopoulos</Name><Description>Cross-scale interactions between mineral and collagen for tendon-bone attachment | IMuBEAM</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Natalia Trayanova</Name><Description>Simulation guidance of ablation therapy for persistent atrial fibrillation Resynchronizing the Failing Heart: Insights from a Multiscale Cardiac Model</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Raj Vadigepalli</Name><Description>"Modeling Central Autonomic Regulatory Network Adaptation to Hypertension” and “Integrated Modeling of Adaptive Neuronal Regulation”	| *Co-leader of Computational Neuroscience Working Group	</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Peter Vekilov</Name><Description>Multiscale Modeling of Sickle Cell Anemia: Methods and Validation</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Marco Viceconti</Name><Description>Insigneo Institute</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Paolo Vicini, Ph.D.</Name><Description>Research Interests: Pharmacokinetics, Pharmacodynamics, Biotherapeutics, Translational Research, Model Identification and Parameter Estimation</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Yoram Vodovotz, Ph.D.</Name><Description>Mathematical Modeling of Inflammation in ARDS	vodovotzy@upmc.edu	Multiscale Systems Biology Working Group; Clinical and Translational Issues</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Jeff Weiss, Ph.D.</Name><Description>FEBio-Finite Elements for Biomechanics and Biophysics</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Ron White, Ph.D.</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Pai-Yei Whung</Name><Description>Population Modeling Working Group</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Bridget Wilson, Ph.D.</Name><Description>Mapping and Modeling ErbB Receptor Membrane Topography</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Beth Winkelstein</Name><Description>Multiscale Modeling of Facet Capsule Mechanobiology | *Co-leader of Biomechanics Working Group</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Raimond Winslow</Name><Description>Cardio Vascular Research Grid Project</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Joyce Wong, Ph.D.</Name><Description>Models to predict protein biomaterial performance | IMuBEAM</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Tom Yankeelov</Name><Description>Image Driven Multi-Scale Modeling to Predict Treatment Response in Breast Cancer | Clinical and Translational Issues Working Group</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Kaiming Ye</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Muhammad Zaman</Name><Description>Modeling bi-directional signaling and cytoskeletal dynamics in 3D cell migrations | *Co-leader of Biomechanics Working Group
</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Yanhang Zhang</Name><Description>Multi-Scale Integration of Extracellular Matrix Mechanics in Vascular Remodeling | Biomechanics Working Group</Description></Stakeholder><Stakeholder StakeholderTypeType="Person"><Name>Xiaobo Zhou, Ph.D.</Name><Description>Modeling the Growth of the MIC Niche at the System Level</Description></Stakeholder></Organization><Vision><Description>Insightful application of ever-increasing advances in the computational modeling of biological, biomedical and behavioral systems, across wide ranges of spatial and temporal scales, has the power to provide a rigorous framework for scientific discovery and translation</Description><Identifier>_009ef1f4-1ab1-11ee-b736-de920f83ea00</Identifier></Vision><Mission><Description>To grow and expand the field of multiscale modeling</Description><Identifier>_009ef35c-1ab1-11ee-b736-de920f83ea00</Identifier></Mission><Value><Name>Science</Name><Description/></Value><Value><Name>Computation</Name><Description/></Value><Value><Name>Rigor</Name><Description/></Value><Value><Name>Insight</Name><Description/></Value><Goal><Name>Mathematical &amp; Computational Models</Name><Description>Develop and apply mechanistic mathematical and computational models over wide ranges of spatial and temporal scales and multiple levels of investigation that include anatomical, physiological, behavioral, social, and environmental elements</Description><Identifier>_009ef3fc-1ab1-11ee-b736-de920f83ea00</Identifier><SequenceIndicator/><Stakeholder><Name/><Description/></Stakeholder><OtherInformation/><Objective><Name>Collaboration &amp; Community</Name><Description>Promote interdisciplinary collaborations and building a diverse community of mathematicians, statisticians, computational scientists, experimentalists, clinicians, public health experts and other stakeholders from all sectors through the combination of different modeling techniques</Description><Identifier>_009ef492-1ab1-11ee-b736-de920f83ea00</Identifier><SequenceIndicator>1</SequenceIndicator><Stakeholder><Name/><Description/></Stakeholder><OtherInformation/></Objective><Objective><Name>Methods &amp; Algorithms</Name><Description>Develop new methods and algorithms for mechanism-based modeling</Description><Identifier>_009ef514-1ab1-11ee-b736-de920f83ea00</Identifier><SequenceIndicator>2</SequenceIndicator><Stakeholder><Name/><Description/></Stakeholder><OtherInformation/></Objective><Objective><Name>AI/ML</Name><Description>Enhance mechanistic machine learning and artificial intelligence</Description><Identifier>_009ef5f0-1ab1-11ee-b736-de920f83ea00</Identifier><SequenceIndicator>3</SequenceIndicator><Stakeholder><Name/><Description/></Stakeholder><OtherInformation/></Objective><Objective><Name>Outcomes &amp; Prediction</Name><Description>Predict reproducible outcomes across spatial and temporal scales</Description><Identifier>_009ef69a-1ab1-11ee-b736-de920f83ea00</Identifier><SequenceIndicator>4</SequenceIndicator><Stakeholder><Name/><Description/></Stakeholder><OtherInformation/></Objective><Objective><Name>Practices &amp; Principles</Name><Description>Ensure the implementation of credible practices for modeling and FAIR principles for scientific data management towards integrating model development, documentation, benchmarking, sharing and reuse</Description><Identifier>_009ef730-1ab1-11ee-b736-de920f83ea00</Identifier><SequenceIndicator>5</SequenceIndicator><Stakeholder><Name/><Description/></Stakeholder><OtherInformation/></Objective><Objective><Name>Models &amp; Insights</Name><Description>Facilitate the dissemination of models and modeling insights within the biomedical, biological, behavioral, clinical, and other IMAG-relevant communities and agencies, and adobption by their stakeholder communities</Description><Identifier>_009ef80c-1ab1-11ee-b736-de920f83ea00</Identifier><SequenceIndicator>6</SequenceIndicator><Stakeholder StakeholderTypeType="Generic_Group"><Name>Biomedical Communities &amp; Agencies</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Generic_Group"><Name>Biological Communities &amp; Agencies</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Generic_Group"><Name>Behavioral Communities &amp; Agencies</Name><Description/></Stakeholder><Stakeholder StakeholderTypeType="Generic_Group"><Name>Clinical Communities &amp; Agencies</Name><Description/></Stakeholder><OtherInformation/></Objective><Objective><Name>Access &amp; Mentorship</Name><Description>Encourage, mentor, and provide access to future generations of multiscale modelers</Description><Identifier>_009ef8a2-1ab1-11ee-b736-de920f83ea00</Identifier><SequenceIndicator>7</SequenceIndicator><Stakeholder StakeholderTypeType="Generic_Group"><Name>Multiscale Modelers</Name><Description/></Stakeholder><OtherInformation/></Objective></Goal></StrategicPlanCore><AdministrativeInformation><StartDate>2023-01-01</StartDate><EndDate>2023-12-31</EndDate><PublicationDate>2023-07-05</PublicationDate><Source>https://www.imagwiki.nibib.nih.gov/content/2023-imagmsm-mission</Source><Submitter><GivenName>Owen</GivenName><Surname>Ambur</Surname><PhoneNumber/><EmailAddress>Owen.Ambur@verizon.net</EmailAddress></Submitter></AdministrativeInformation></PerformancePlanOrReport>